The contact owns a 2017 Mercedes-Benz E300. The contact stated while driving at an undisclosed speed, the accelerator pedal was depressed; however, the vehicle failed to accelerate as intended. The contact stated that the gear shifter failed to shift into the drive as intended. In addition, the contact stated that when the gear shifter was shifted into drive after several attempts, the gear shifter shifted to drive three instead of drive one. No warning light was illuminated. The vehicle was taken to the dealer where it was diagnosed with a transmission control module and a shift-level module failure. The contact was informed that the transmission control module and shift level module needed to be replaced. The vehicle was not repaired. In addition, the contact stated that when the failure had started, the transmission slipped, and the gear shifter independently shifted into neutral. The contact stated that the failure persisted. The manufacturer was made aware of the failure. The contact was advised to contact the NHTSA Hotline to report the failure. The failure mileage was approximately 43,000.