The contact owns a 2016 Mercedes-Benz GLE450. The contact stated while driving at an undisclosed speed, the front roof panel detached and flew off the vehicle. The vehicle was not diagnosed or repaired by an independent mechanic or the dealer. The contact referenced an unknown recall; however, the VIN was not included in the recall. The manufacturer was made aware of the failure but provided no assistance. The contact was advised to contact the NHTSA Hotline to report the failure. The failure mileage was approximately 104,620.