The contact owns a 2021 GMC Acadia. The contact stated that the door locks failed to lock and unlock while using the key fob or the buttons on the outside or inside the vehicle. The locks failed to operate as needed until after the vehicle was driven. The contact had to manually lock the door; however, after locking the door, the contact was unable to unlockthe vehicle. The contact had to climb through the trunk of the vehicle to enter the vehicle. The contact stated that the failure only occurred while it was raining. The vehicle was taken to the dealer, who was unable to duplicate the failure because it was not raining at the time. The vehicle was not diagnosed or repaired. The manufacturer was informed of the failure and confirmed that the vehicle was not included in GMC Special Coverage: N22378380. The manufacturer referred the contact to the NHTSA Hotline to report the failure. The failure mileage was approximately 37,000.