Most likely a connecting rod bearing failure leading to catastrophic engine failure per dealership service department. Vehicle is currently available for inspection. Safety was put at risk by engine part (likely connecting rod bearing) coming loose. It flew through my oil pan and bounced off the road, fortunately no people or other vehicles were hit by the part. Vehicle lost power and engine started smoking, oil spilled all over the road. I had to evacuate vehicle on busy highway (70 mph speed limit) since it was smoking. The vehicle was towed to the dealer which inspected it and said most likely connecting rod bearing failure but could not confirm unless engine taken apart. To my knowledge no one else has inspected it. All service for the life of the vehicle has been performed at Honda dealerships at recommended times. A check engine light had come on shortly before the problem occurred.